Binding of acridine orange to transfer RNA and photodynamic inactivation.
نویسندگان
چکیده
منابع مشابه
Mechanisms of photodynamic inactivation of acridine orange-sensitized transfer RNA: participation of singlet oxygen and base damage leading to inactivation.
Photodynamic action/Acridine orange/tRNA/Guanine/Singlet oxygen The photodynamic inactivation of acridine orange (AO)-sensitized tRNA was investigated with respect to the type of photochemical pathways and the base damage leading to the inactivation. The diagnostic tests for singlet oxygen (1O2), namely the enhancement effect of deuterium oxide (D2O) and the inhibition effect by sodium azide, i...
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The kinetics of the photodynamic desactivation of lysozyme in presence of acridine orange as the sensitizer have been investigated in detail varying oxygen, protein, dye concentration, ionic strength and pH value. The kinetics can be approximately described as an over all pseudo-first-order rate process. Changing the solvent from water to D2O or by quenching experiments in presence of azide ion...
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DNA/RNA, present in almost every cell, has been a hot research topic in a wide range of areas, including biology, physics, chemistry and polymer engineering. Naturally, to image DNA and facilitate DNA/RNA-related questions becomes an interesting question itself. Since 50 years ago people have been discovering and developing families of fluorescence dyes (from Acridine orange to YOYO-1) with uni...
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Limb salvage involving wide resection and reconstruction is now well established for managing musculoskeletal sarcomas. However, involvement of major nerves and vessels with a large volume of muscle and skin may result in a useless limb, contributing to depression and a low quality of life. We have been studying alternative treatments for musculoskeletal sarcoma since 1990, and have recently es...
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We recently established the new limb salvage modality of acridine orange (AO) therapy (AOT), in an attempt to develop minimally invasive limb salvage surgery with minimal damage of normal tissues and a low risk of local recurrence. The treatment modality consists of intraoperative photodynamic surgery (iPDS) and photodynamic therapy (iPDT), followed by postoperative radiodynamic therapy (RDT) u...
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ژورنال
عنوان ژورنال: Journal of Radiation Research
سال: 1986
ISSN: 0449-3060,1349-9157
DOI: 10.1269/jrr.27.325